Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study
Identifieur interne : 000413 ( Main/Exploration ); précédent : 000412; suivant : 000414Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study
Auteurs : Francesco Lapi [Italie, Canada] ; Laurent Azoulay [Canada] ; Hui Yin [Canada] ; Sharon J. Nessim [Canada] ; Samy Suissa [Canada]Source :
- BMJ : British Medical Journal [ 1756-1833 ] ; 2013.
Abstract
Objectives To assess whether a double therapy combination consisting of diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers with addition of non-steroidal anti-inflammatory drugs (NSAIDs) and the triple therapy combination of two of the aforementioned antihypertensive drugs to which NSAIDs are added are associated with an increased risk of acute kidney injury. Design Retrospective cohort study using nested case-control analysis. Setting General practices contributing data to the UK Clinical Practice Research Datalink linked to the Hospital Episodes Statistics database. Participants A cohort of 487 372 users of antihypertensive drugs. Main outcome measures Rate ratios with 95% confidence intervals of acute kidney injury associated with current use of double and triple therapy combinations of antihypertensive drugs with NSAIDs. Results During a mean follow-up of 5.9 (SD 3.4) years, 2215 cases of acute kidney injury were identified (incidence rate 7/10 000 person years). Overall, current use of a double therapy combination containing either diuretics or angiotensin converting enzyme inhibitors or angiotensin receptor blockers with NSAIDs was not associated with an increased rate of acute kidney injury. In contrast, current use of a triple therapy combination was associated with an increased rate of acute kidney injury (rate ratio 1.31, 95% confidence interval 1.12 to 1.53). In secondary analyses, the highest risk was observed in the first 30 days of use (rate ratio 1.82, 1.35 to 2.46). Conclusions A triple therapy combination consisting of diuretics with angiotensin converting enzyme inhibitors or angiotensin receptor blockers and NSAIDs was associated with an increased risk of acute kidney injury. The risk was greatest at the start of treatment. Although antihypertensive drugs have cardiovascular benefits, vigilance may be warranted when they are used concurrently with NSAIDs.
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DOI: 10.1136/bmj.e8525
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Nessim</name></author><author><name sortKey="Suissa, Samy" sort="Suissa, Samy" uniqKey="Suissa S" first="Samy" last="Suissa">Samy Suissa</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5C0DE6B94EB1AFD0895402DAC030BB2BED3B9BE3</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/bmj.e8525</idno><idno type="url">https://api.istex.fr/document/5C0DE6B94EB1AFD0895402DAC030BB2BED3B9BE3/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001145</idno><idno type="wicri:Area/Istex/Curation">001121</idno><idno type="wicri:Area/Istex/Checkpoint">000069</idno><idno type="wicri:Area/Main/Merge">000413</idno><idno type="wicri:Area/Main/Curation">000413</idno><idno type="wicri:Area/Main/Exploration">000413</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study</title><author><name sortKey="Lapi, Francesco" sort="Lapi, Francesco" uniqKey="Lapi F" first="Francesco" last="Lapi">Francesco Lapi</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence</wicri:regionArea><wicri:noRegion>50139 Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Azoulay, Laurent" sort="Azoulay, Laurent" uniqKey="Azoulay L" first="Laurent" last="Azoulay">Laurent Azoulay</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Yin, Hui" sort="Yin, Hui" uniqKey="Yin H" first="Hui" last="Yin">Hui Yin</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Nessim, Sharon J" sort="Nessim, Sharon J" uniqKey="Nessim S" first="Sharon J" last="Nessim">Sharon J. Nessim</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Suissa, Samy" sort="Suissa, Samy" uniqKey="Suissa S" first="Samy" last="Suissa">Samy Suissa</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author></analytic><monogr></monogr><series><title level="j">BMJ : British Medical Journal</title><title level="j" type="abbrev">BMJ</title><idno type="eISSN">1756-1833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="2013">2013</date><biblScope unit="volume">346</biblScope></imprint></series><idno type="istex">5C0DE6B94EB1AFD0895402DAC030BB2BED3B9BE3</idno><idno type="DOI">10.1136/bmj.e8525</idno><idno type="href">bmj-346-bmj-e8525.pdf</idno><idno type="ArticleID">lapf007039</idno><idno type="local">bmj;346/jan08_12/e8525</idno></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives To assess whether a double therapy combination consisting of diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers with addition of non-steroidal anti-inflammatory drugs (NSAIDs) and the triple therapy combination of two of the aforementioned antihypertensive drugs to which NSAIDs are added are associated with an increased risk of acute kidney injury. Design Retrospective cohort study using nested case-control analysis. Setting General practices contributing data to the UK Clinical Practice Research Datalink linked to the Hospital Episodes Statistics database. Participants A cohort of 487 372 users of antihypertensive drugs. Main outcome measures Rate ratios with 95% confidence intervals of acute kidney injury associated with current use of double and triple therapy combinations of antihypertensive drugs with NSAIDs. Results During a mean follow-up of 5.9 (SD 3.4) years, 2215 cases of acute kidney injury were identified (incidence rate 7/10 000 person years). Overall, current use of a double therapy combination containing either diuretics or angiotensin converting enzyme inhibitors or angiotensin receptor blockers with NSAIDs was not associated with an increased rate of acute kidney injury. In contrast, current use of a triple therapy combination was associated with an increased rate of acute kidney injury (rate ratio 1.31, 95% confidence interval 1.12 to 1.53). In secondary analyses, the highest risk was observed in the first 30 days of use (rate ratio 1.82, 1.35 to 2.46). Conclusions A triple therapy combination consisting of diuretics with angiotensin converting enzyme inhibitors or angiotensin receptor blockers and NSAIDs was associated with an increased risk of acute kidney injury. The risk was greatest at the start of treatment. Although antihypertensive drugs have cardiovascular benefits, vigilance may be warranted when they are used concurrently with NSAIDs.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Lapi, Francesco" sort="Lapi, Francesco" uniqKey="Lapi F" first="Francesco" last="Lapi">Francesco Lapi</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Lapi, Francesco" sort="Lapi, Francesco" uniqKey="Lapi F" first="Francesco" last="Lapi">Francesco Lapi</name></noRegion><name sortKey="Azoulay, Laurent" sort="Azoulay, Laurent" uniqKey="Azoulay L" first="Laurent" last="Azoulay">Laurent Azoulay</name><name sortKey="Nessim, Sharon J" sort="Nessim, Sharon J" uniqKey="Nessim S" first="Sharon J" last="Nessim">Sharon J. Nessim</name><name sortKey="Suissa, Samy" sort="Suissa, Samy" uniqKey="Suissa S" first="Samy" last="Suissa">Samy Suissa</name><name sortKey="Suissa, Samy" sort="Suissa, Samy" uniqKey="Suissa S" first="Samy" last="Suissa">Samy Suissa</name><name sortKey="Yin, Hui" sort="Yin, Hui" uniqKey="Yin H" first="Hui" last="Yin">Hui Yin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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